A Systematic Analysis of Compounds Present in Ocimum Tenuiflorum (Tulsi) Regarding its Anti-Inflammatory Properties Using In-Silico Techniques

Abstract

The objective of this study was to gather data, create a database of the compounds present in Ocimum tenuiflorum (O. tenuiflorum), and gather related literature on the compounds found. A thorough literature search was performed to gather information on compounds present in O. tenuiflorum, including chemical structures, relative abundance, presence in different plant parts, and availability from chemical supply vendors. The compounds’ chemical structures were refined using Discovery Studio Visualizer and Chimera software for future in-silico docking studies. The structures with cleaned structural geometry were obtained through D.S. Visualizer for docking in the future. From the literature search of previously presented articles, it was found that methyl eugenol had the greatest percent composition in O. tenuiflorum. After searching   the Protein Data Bank, COX-1, COX-2, and NF Kappa B were found to be the main protein targets of O. tenuiflorum compounds in the arachidonic acid inflammatory pathway. Thus, the   anti-inflammatory properties of O. tenuiflorum have been analyzed in this article for future in silico docking.